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Article

Essential role of ICAM-1 in aldosterone-induced atherosclerosis.

International journal of cardiology - 1 Apr 2017

Marzolla Vincenzo, Armani Andrea, Mammi Caterina, Moss Mary E, Pagliarini Vittoria, Pontecorvo Laura, Antelmi Antonella, Fabbri Andrea, Rosano Giuseppe, Jaffe Iris Z, Caprio Massimiliano

Abstract excerpt

OBJECTIVE: Elevated aldosterone is associated with increased risk of atherosclerosis complications, whereas treatment with mineralocorticoid receptor (MR) antagonists decreases the rate of cardiovascular events. Here we test the hypothesis that aldosterone promotes early atherosclerosis by modulating intercellular adhesion molecule-1 (ICAM-1) expression and investigate the molecular mechanisms by which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28089144
DOI: 10.1016/j.ijcard.2017.01.013
PMCID: PMC5890338

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