Article

Particle Phagocytosis Amplifies Secretion of Small Extracellular Vesicles in Macrophages

2026-02-02

Abstract excerpt

<h4>ABSTRACT</h4> Macrophage-derived extracellular vesicles (EVs) are critical mediators of immune communication and tissue homeostasis, yet the exogenous factors that regulate their release and composition remain poorly defined. Here, we identify phagocytosis of particulate materials as a direct and general driver of macrophage small EV production through a lysosome-linked mechanism. Across primary and engineere...

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Literature Corpus work: 8178cd95-d2a7-54a3-8c3f-bfd5dd8a7a2e
DOI: 10.64898/2026.01.29.701815

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