Article

Design of combination therapy for engineered bacterial therapeutics in non-small cell lung cancer

2022-09-27

Abstract excerpt

Synthetic biology enables the engineering of bacteria to safely deliver potent payloads to tumors for effective anti-cancer therapies. However, a central challenge for translation is determining ideal bacterial therapy candidates for specific cancers and integrating them with other drug treatment strategies to maximize efficacy. To address this, we designed a screening and evaluation pipeline for characterization...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8cae8ddc-1a77-5edf-a9e7-859068cc4724
DOI: 10.21203/rs.3.rs-2085639/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Design of combination therapy for engineered bacterial therapeutics in non-small cell lung cancerDOI 10.21203/rs.3.rs-2085639/v1Read

Rapid screening of engineered microbial therapies in a 3-D multicellular modelSemantic proximity Read

Synthetic lethality in lung cancer and translation to clinical therapiesSemantic proximity Read

Unbiased peptoid combinatorial cell screen identifies plectin protein as a potential biomarker for lung cancer stem cellsSemantic proximity Read

Targeted Anti Bacterial TherapySemantic proximity Read

Programmable genetic control of tumor-colonizing Bifidobacterium longum for intratumoral therapeutic delivery and biocontainmentSemantic proximity Read

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organismSemantic proximity Read

Programmable bacteria induce durable tumor regression and systemic antitumor immunitySemantic proximity Read

Combination of Polymeric Micelle Formulation of TGFβ Receptor Inhibitors and Paclitaxel Produce Consistent Response Across Different Mouse Models of TNBCSemantic proximity Read

Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc, a key driver of tumourigenesis.Semantic proximity Read

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.Semantic proximity Read

Expanding antimicrobial chemical space by engineering drug safetySemantic proximity Read

Anti-tumoral effect of the mitochondrial target domain of Noxa delivered by an engineered Salmonella typhimurium.Semantic proximity Read