Article

Hyperactivation of p53 using CRISPRa kills human papillomavirus driven cervical cancer cells

2022-09-07

Abstract excerpt

Clinical trials and proof-of-concept pre-clinical work for different cancers has shown relatively positive outcomes and tumour killing when p53, a well-established tumour suppressor, levels and function is restored. Human papillomavirus (HPV) driven cancers encode the E6 oncoprotein that degrades p53 to allow HPV-driven carcinogenic process to proceed. Indeed, there have been several attempts in the past to revive...

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Literature Corpus work: 4ee708ca-4616-5aba-afe6-47a2fbee4d36
DOI: 10.21203/rs.3.rs-2015515/v1

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