SLAMF7 Regulates Inflammatory Response In Macrophage During Polymicrobial Sepsis

Abstract excerpt

Uncontrolled microbe-triggered inflammation results in multiple organ injury and shock in sepsis. However, the regulatory mechanisms that restrict cytokine storm are still elusive. Using gene screening, we identified an immunoglobulin-like receptor called Signaling Lymphocyte Activation Molecular Family-7 (SLAMF7), as a key regulator of inflammation during sepsis. We found that the expression of SLAMF7 on monocyte...

Topics

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• Cell Death
• Clustered Regularly Interspaced Short Palindromic Repeats
• Gene Editing
• Gene Knockdown Techniques
• Gene Targeting
• Neutrophils
• Receptors, Immunologic
• Sepsis

Identifiers and source

Literature Corpus work

8ca96733-29f0-53c3-940e-63331532ffa3

DOI

10.21203/rs.3.rs-214049/v1