Article

SAMSN1 causes sepsis immunosuppression by inducing macrophages to express coinhibitory molecules that causes T cell exhaustion via KEAP1-NRF2 signaling

2024-10-06

Abstract excerpt

Immunosuppression has been found to be closely related to the pathogenesis of sepsis, but the underlying mechanisms have not yet been fully elucidated. In this study, we identified that SH3 domain and nuclear localization signals 1 (SAMSN1), a gene encoding a putative adaptor protein, plays an important role in immunosuppression in sepsis. The expression of SAMSN1 was significantly increased in patients with sepsi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 235e127b-d6dd-57de-a122-1671fc7192f6
DOI: 10.1101/2024.10.03.24314746

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SAMSN1 causes sepsis immunosuppression by inducing macrophages to express coinhibitory molecules that causes T cell exhaustion via KEAP1-NRF2 signalingDOI 10.1101/2024.10.03.24314746Read

Role of Cellular Senescence Genes and Immune Infiltration in Sepsis and Sepsis-Induced ARDS Based on Bioinformatics AnalysisSemantic proximity Read

Dysregulation of “Don’t Eat Me” Signaling–Related Genes in Sepsis: A Targeted Transcriptomic AnalysisSemantic proximity Read

Identification of qualitative characteristics of immunosuppression in sepsis based on immune-related genes and immune infiltration featuresSemantic proximity Read

Role of cellular senescence genes and Immune Infiltration in sepsis and sepsis-induced ARDS based on bioinformatics analysisSemantic proximity Read

Identification of key immune genes for sepsis-induced ARDS based on bioinformatics analysisSemantic proximity Read

ITGB2 and ICAM3 predict increased survival of sepsis with decreased intercellular communication in Cytotoxic CD8+ T- cellsSemantic proximity Read

Identification and analysis of the endoplasmic reticulum stress hub genes in sepsis-associated ARDSSemantic proximity Read

Integrated Bioinformatics Analysis Identifies and Validates Novel Cellular Senescence-Associated Genes in Sepsis and Sepsis-Induced ARDSSemantic proximity Read

A comprehensive analysis of immune features and construction of an immune gene diagnostic model for sepsisSemantic proximity Read

A Meta-Analysis of Whole Blood Transcriptome Reveals Association of Increased Neutrophil Activity and T cell Suppression in SepsisSemantic proximity Read

Identification of immune-related lncRNAs in peripheral blood of sepsis by transcriptome sequencing and analysis core lncRNA PRKCQ-AS1 roles in prognosis and progression of sepsisSemantic proximity Read

Malat1 regulates PMN-MDSC expansion and immunosuppression through p-STAT3 ubiquitination in sepsisSemantic proximity Read