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Mapping Haemagglutinin Residues Driving Antigenic Diversity in H5Nx Avian Influenza Viruses

2025-06-18

Abstract excerpt

Since its emergence in 1996, the H5 avian influenza virus (AIV) A/Goose/Guangdong/1/1996 (Gs/GD) haemagglutinin (HA) has evolved into over 30 genetically and antigenically distinct clades, including the widespread clade 2.3.4.4b. Vaccination is widely used in endemic regions to reduce poultry losses and zoonotic risk. However, the evolving antigenic diversity and global co-circulation of multiple clades challenges...

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Literature Corpus work: 8c9ff0e9-fb29-5479-a76b-02e7dd79a9eb
DOI: 10.1101/2025.06.18.660338

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