Extent of Antigenic Cross-Reactivity among Highly Pathogenic H5N1 Influenza Viruses

Abstract excerpt

Highly pathogenic H5N1 avian influenza viruses emerged in 1996 and have since evolved so extensively that a single strain can no longer be used as a prepandemic vaccine or diagnostic reagent. We therefore sought to identify the H5N1 strains that may best serve as cross-reactive diagnostic reagents. We compared the cross-reactivity of 27 viruses of clades 0, 1, 2.1, 2.2, 2.3, and 4 and of four computationally...

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• Animal Disease Management and Epidemiology
• Influenza Virus Research Studies
• Respiratory viral infections research