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Article

Use of Antigenic Cartography in Vaccine Seed Strain Selection

1 Mar 2010

Abstract excerpt

Human influenza A viruses are classic examples of antigenically variable pathogens that have a seemingly endless capacity to evade the host's immune response. The viral hemagglutinin (HA) and neuraminidase (NA) proteins are the main targets of our antibody response to combat infections. HA and NA continuously change to escape from humoral immunity, a process known as antigenic drift. As a result of antigenic...

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PMID: 20521635
DOI: 10.1637/8740-032509-resnote.1

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