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Article

Impact of loss-of-function variations of PCSK9 on LDLR interaction and dynamics: Implications for heart function.

Biochemical and biophysical research communications - 5 Feb 2026

Kulshreshtha Akanksha, Bhatnagar Sonika

Abstract excerpt

Integrative Biology research has deepened our understanding of various diseases particularly by elucidating the impact of nonsynonymous single nucleotide polymorphisms (nsSNPs) on disease and diagnosis. PCSK9 is an important cholesterol regulator, and genetic variations in this protein can influence cardiovascular risk. Loss-of-function (LOF) mutations in PCSK9 gene are linked to reduced plasma LDL cholesterol...

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Share to Hypercholesterolemia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41499931
DOI: 10.1016/j.bbrc.2025.153224

Genes

PCSK9
LDLR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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