Article

The SUMO-interacting Motif in NS2 promotes adaptation of avian influenza virus to mammals

2022-12-11

Abstract excerpt

<h4>SUMMARY</h4> Species differences in the host factor ANP32A/B result in the restriction of avian influenza virus polymerase (vPol) in mammalian cells. Efficient replication of avian influenza viruses in mammalian cells often requires adaptive mutations, such as PB2-E627K, to enable the virus to utilize mammalian ANP32A/B. However, the molecular basis for the productive replication of avian influenza viruses wi...

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Literature Corpus work: 8c68b09e-729c-526e-843c-eea5b7699adc
DOI: 10.1101/2022.12.11.519849

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