Article
The SUMO-interacting motif in NS2 promotes adaptation of avian influenza virus to mammals.
Science advances - 14 Jul 2023
Sun Liuke, Kong Huihui, Yu Mengmeng, Zhang Zhenyu, Zhang Haili, Na Lei, Qu Yuxing, Zhang Yuan, Chen Hualan, Wang Xiaojun
Abstract excerpt
Species differences in the host factor ANP32A/B result in the restriction of avian influenza virus polymerase (vPol) in mammalian cells. Efficient replication of avian influenza viruses in mammalian cells often requires adaptive mutations, such as PB2-E627K, to enable the virus to use mammalian ANP32A/B. However, the molecular basis for the productive replication of avian influenza viruses without prior...
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