Article

Towards In Vivo Proof-of-Binding of 18F-labeled Inhibitor [18F]TRACK to Peripheral Tropomyosin Receptor Kinases

2022-05-10

Abstract excerpt

<title>Abstract</title> <p>Background Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are a family of tyrosine kinases primarily expressed in neuronal cells of the brain. Identification of oncogenic alterations in Trk expression as a driver in multiple tumor types has increased interest in their role in human cancers. Recently, first and second generation <sup>11</sup>C and <sup>18</sup>F-labeled Trk inhibitors...

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Literature Corpus work: 8c4c37c5-f4c5-5bcf-b91f-b0d38fb48ab1
DOI: 10.21203/rs.3.rs-1499067/v1

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