Article

DTPA-Receptor – A novel reporter gene system for the specific and sensitive PET imaging of CAR-T cells and AAV transduced cells

2023-08-23

Abstract excerpt

<title>Abstract</title> Advanced Therapy Medicinal Products (ATMPs), such as cell and gene therapies, necessitate a reliable diagnostic method for quantitative monitoring. We developed a novel reporter gene system for PET imaging consisting of a membrane-anchored Anticalin protein (DTPA-R) that acts as a high-affinity receptor for the radioligand [18F]F-DTPA•TbIII. The reporter protein sh...

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Identifiers and source

Literature Corpus work: 0217a99e-aaf6-51ca-9ab8-42bb12a583f8
DOI: 10.21203/rs.3.rs-3200226/v1

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