Article

RNA sensing via LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency

2021-10-28

Abstract excerpt

RNA editing by the enzyme Adenosine Deaminase Acting on RNA 1 (ADAR1) is an important mechanism by which cells avoid innate immune responses to some endogenous RNAs. In ADAR1-deficient cells, unedited self RNAs can form base-paired structures that resemble viral RNAs and inadvertently activate antiviral innate immune pathways that lead to the induction of type I interferon (IFN). Rare mutations in ADAR1 cause Aica...

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Literature Corpus work: 8c034a34-c883-5d11-9202-c109671c6ae3
DOI: 10.1101/2021.10.27.465188

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