Article

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation

2022-09-22

Abstract excerpt

Gut microbiota plays an important role in drug modification, transformation and degradation, which are factors that need to be considered in personalized therapy. Acarbose, an inhibitor of α-glucosidase, is used as a first-line drug for the treatment of type 2 diabetes; however, its clinical effects vary greatly among individuals, and the underlying mechanisms relating to the contribution of gut microbes remain to...

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Literature Corpus work: 8be1b42b-e1f3-5212-85fc-6153dfdec200
DOI: 10.21203/rs.3.rs-2086719/v1

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