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Article

Unravelling sex differences in the genetic architecture of anxiety.

Psychological medicine - 11 Jun 2026

Hu Jihua, Lupton Michelle K, Byrne Enda M, Martin Nicholas G, Whiteman David C, Olsen Catherine M, Thomas Jodi T, Medland Sarah E, Grasby Katrina L, Mitchell Brittany L

Abstract excerpt

BACKGROUND: Anxiety disorders show striking sex differences in prevalence, symptoms, and clinical characteristics, shaping how they manifest and are experienced. METHODS: Here, we report the first sex-specific meta-analysis of genome-wide association studies (GWAS) of anxiety, leveraging two of the largest biobank datasets, UK Biobank and All of Us, comprising 85,042 female cases with 196,789 controls and 36,732...

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Identifiers

PMID: 42272362
DOI: 10.1017/S0033291726104760
PMCID: PMC13280693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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