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mRNA Profiling of Inflammatory Stress Responses after Aquaporin-4 Antibody and Human Complement Treatment Reveals Upregulation of NF-κB and IL6 Pathways

2025-09-17

Abstract excerpt

<title>Abstract</title> <p> Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease affecting the central nervous system via autoantibodies that target the water channel aquaporin-4 (AQP4) on astrocytes. Binding to AQP4 initiates activation of innate immune components, especially the complement system. Both <italic>in vivo</italic> and <italic>in vitro</italic> models have been developed...

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Literature Corpus work
8b821fb4-0a11-5fc9-a57f-d6ff108afc86
DOI
10.21203/rs.3.rs-7064018/v1
Open publication

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mRNA Profiling of Inflammatory Stress Responses after Aquaporin-4 Antibody and Human Complement Treatment Reveals Upregulation of NF-κB and IL6 PathwaysDOI 10.21203/rs.3.rs-7064018/v1
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