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Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders

9 Mar 2021

Abstract excerpt

Aquaporin 4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG+NMOSD) is an autoimmune astrocytopathic disease pathologically characterized by the massive destruction and regeneration of astrocytes with diverse types of tissue injury with or without complement deposition. However, it is unknown whether this diversity is derived from differences in pathological processes or temporal changes....

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PMID: 33711152
DOI: 10.1093/brain/awab102

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