Mitophagy in cardiovascular diseases: mechanisms and potential therapies

Abstract excerpt

Mitophagy, the selective autophagic degradation of mitochondria, is a critical process for preserving mitochondrial quality and cellular homeostasis in the cardiovascular system. This review systematically outlines the principal molecular mechanisms underlying mitophagy, focusing on the PTEN-induced putative kinase 1 (PINK1)-Parkin pathway and receptor-mediated pathways involving proteins such as BCL2/adenovirus E...

Topics

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• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Diet and metabolism studies
• Diet, Metabolism, and Disease
• MicroRNA in disease regulation
• Mitochondrial Function and Pathology
• Neurological Disease Mechanisms and Treatments
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

eb3fef01-8fac-56f7-b9ac-8c5cb1f1fae4

DOI

10.22541/au.176368158.83446849/v1