Article

RUVBL1 and RUVBL2 as novel druggable DNA Damage Response regulators in the N-Myc regulatory network in neuroblastoma

2023-11-20

Abstract excerpt

<title>Abstract</title> <p>High-risk neuroblastoma (NB) accounts for about 50% of all cases. These tumours are characterized by <italic>MYCN</italic> amplification and high <italic>MYC</italic> gene expression and patients have a high relapse rate despite intensive therapies, hence the need for safer and more effective drugs. Strategies to develop inhibitors that directly target the MYC proteins have been elusive...

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Literature Corpus work: 99a91ef2-82d1-5c6d-a451-2d404ad29ac2
DOI: 10.21203/rs.3.rs-3206227/v1

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