Article

Phosphorylation of TOPK at Y272 by FYN enhances proliferation and metastasis of gastric cancer

2022-12-05

Abstract excerpt

<title>Abstract</title> <p>Background FYN is a nonreceptor tyrosine kinase that regulates diverse pathological processes. The pro-cancer role of FYN in multiple malignancies has been elucidated. However, the mechanisms that FYN promotes gastric cancer(GC) progression remain largely unknown. Methods In vitro and in vivo assays were used to investigate the function of FYN. FYN, TOPK, p-TOPK expression in GC speci...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8af7dcde-d3b1-5aba-b3ce-5fb832ea187b
DOI: 10.21203/rs.3.rs-2295760/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of TOPK at Y272 by FYN enhances proliferation and metastasis of gastric cancerDOI 10.21203/rs.3.rs-2295760/v1Read

FYN: emerging biological roles and potential therapeutic targets in cancerSemantic proximity Read

<i>TNK</i><i>2</i> gene amplification is a novel predictor of a poor prognosis in patients with gastric cancerSemantic proximity Read

Knockdown AHNAK2 inhibits the progression of gastric cancer via the Wnt/β-catenin signaling pathwaySemantic proximity Read

ATP4B suppresses cell proliferation and migration via mitochondrial/p53/NF-κB pathway in gastric cancerSemantic proximity Read

YY1: a key regulator inhibits gastric cancer ferroptosis and mediating Apatinib-resistanceSemantic proximity Read

Pseudophosphatase STYX is induced by Helicobacter pylori and promotes gastric cancer progression by inhibiting FBXO31 functionSemantic proximity Read

The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cellsSemantic proximity Read

The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathwaySemantic proximity Read

YY1: a key regulator inhibits gastric cancer ferroptosis and mediating apatinib-resistanceSemantic proximity Read

PHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOSSemantic proximity Read

Protein Phosphatase 2A Inhibits Gastric Cancer Cell Glycolysis by Reducing MYC SignalingSemantic proximity Read

Bcl-2-associated Transcription Factor 1 Phosphorylation Mediated DNA Damage Response in Gastric CancerSemantic proximity Read