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YY1: a key regulator inhibits gastric cancer ferroptosis and mediating apatinib-resistance

12 Feb 2024

Abstract excerpt

OBJECTIVE: Gastric cancer (GC) stands as a prevalent and deadly global malignancy. Despite its role as a preoperative neoadjuvant therapy, Apatinib's effectiveness is curtailed among GC patients exhibiting elevated YY1 expression. YY1's connection to adverse prognosis, drug resistance, and GC metastasis is established, yet the precise underlying mechanisms remain elusive. This study aims to unravel potential...

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PMID: 38347631
DOI: 10.1186/s12935-024-03262-z

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