Article

Pathway-Centric Transcriptomic Profiling of Middle Ear Cholesteatoma Identifies Selective Dysregulation of the IL-6/JAK-STAT/MAPK and MMP9/ZEB1 Pathways

2026-08-18

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Cholesteatoma is a destructive lesion of the middle ear characterized by hyperproliferative keratinocytes and chronic bone erosion. Although histologically benign, its aggressive behaviour causes severe otologic complications. The precise molecular mechanisms dividing active drivers from unaltered regulators within key pathogenic pathways remain poorly defin...

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Literature Corpus work: 9790ef85-6244-5599-8d85-046c43ec0a0b
DOI: 10.21203/rs.3.rs-10722537/v1

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Pathway-Centric Transcriptomic Profiling of Middle Ear Cholesteatoma Identifies Selective Dysregulation of the IL-6/JAK-STAT/MAPK and MMP9/ZEB1 PathwaysDOI 10.21203/rs.3.rs-10722537/v1Read

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