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Club cell-specific role of programmed cell death 5 in pulmonary fibrosis

19 May 2021

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibrosis is significantly diminished by club cell-specific deletion of Pdcd5 gene. PDCD5 mediates β-catenin/Smad3...

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PMID: 34011956
DOI: 10.1038/s41467-021-23277-8

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