γδ T cells impair airway macrophage differentiation in lung adenocarcinoma

Abstract excerpt

Protecting mucosal barriers, γδ T cells hold promise for the development of new cancer immunotherapies. In mice, γδ T cells can largely be segregated into CD27 + and CD27 − cells, and their functions are modulated by interactions with surrounding cells. However, which cells communicate directly with γδ T cells in lung adenocarcinoma remains unknown. To address this, we combined flow cytometry, confocal microscop...

Topics

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• CAR-T cell therapy research
• Immune Cell Function and Interaction
• Immunotherapy and Immune Responses
• Neoplasms
• Phenotype
• Receptors, Antigen, T-Cell, gamma-delta
• T-Lymphocyte Subsets
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

8a4d7bf3-7e84-5b5e-b17c-a2bbb4cef46d

DOI

10.1101/2023.09.14.557344