Article
Lynch Syndrome-associated Genomic Variants.
Journal of gastrointestinal and liver diseases : JGLD - 29 Sept 2024
Botea Robert, Piron-Dumitrascu Madalina, Georgescu Tiberiu Augustin, Bohiltea Camil Laurentiu, Voinea Silviu Cristian, Varlas Valentin Nicolae, Iacoban Simona Raluca, Suciu Nicolae
Abstract excerpt
BACKGROUND AND AIMS: Lynch Syndrome, a hereditary disorder characterized by germline mutations in mismatch repair (MMR) genes, is a major contributor to colorectal cancers. It has also been identified in endometrial cancer. Despite the established role of MMR deficiency in tumorigenesis, the specific genomic alterations driving Lynch syndrome-associated endometrial cancer, and their overlap with colorectal...
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