Article

Analysis of AlphaFold and molecular dynamics structure predictions of mutations in serpins

2023-02-03

Abstract excerpt

Serine protease inhibitors (serpins) include thousands of structurally conserved proteins playing key roles in many organisms. Mutations affecting serpins may disturb their conformation, leading to inactive forms. Unfortunately, conformational consequences of mutations affecting serpins are difficult to predict. In this study we integrate experimental data of patients with mutations affecting one serpin with the p...

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Literature Corpus work: 8a3e185b-5fb7-5649-abc9-acecb99798e1
DOI: 10.1101/2023.01.31.526415

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