Article
Full-scale network analysis reveals properties of the FV protein structure organization.
Scientific reports - 12 Jun 2023
Ferreira-Martins André J, Castaldoni Rodrigo, Alencar Brenno M, Ferreira Marcos V, Nogueira Tatiane, Rios Ricardo A, Lopes Tiago J S
Abstract excerpt
Blood coagulation is a vital process for humans and other species. Following an injury to a blood vessel, a cascade of molecular signals is transmitted, inhibiting and activating more than a dozen coagulation factors and resulting in the formation of a fibrin clot that ceases the bleeding. In this process, the Coagulation factor V (FV) is a master regulator, coordinating critical steps of this process. Mutations...
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