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Article

Prediction of hemophilia A severity using a small-input machine-learning framework.

NPJ systems biology and applications - 25 May 2021

Lopes Tiago J S, Rios Ricardo, Nogueira Tatiane, Mello Rodrigo F

Abstract excerpt

Hemophilia A is a relatively rare hereditary coagulation disorder caused by a defective F8 gene resulting in a dysfunctional Factor VIII protein (FVIII). This condition impairs the coagulation cascade, and if left untreated, it causes permanent joint damage and poses a risk of fatal intracranial hemorrhage in case of traumatic events. To develop prophylactic therapies with longer half-lives and that do not...

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Identifiers

PMID: 34035274
DOI: 10.1038/s41540-021-00183-9
PMCID: PMC8149871

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