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Article

The Lon-2 protease of Borrelia burgdorferi is critical for infection in the mammalian host.

Molecular microbiology - 1 May 2020

Mason Charlotte, Thompson Christina, Ouyang Zhiming

Abstract excerpt

Borrelia burgdorferi encodes a functional homolog of canonical Lon protease termed Lon-2. To date, the contribution of Lon-2 to B. burgdorferi fitness and infection remains unexplored. Herein, we showed that expression of lon-2 was highly induced during animal infection, suggesting that Lon-2 is important for B. burgdorferi infection. We further generated a lon-2 deletion mutant. Compared with that of wild-type...

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Identifiers

PMID: 31955462
DOI: 10.1111/mmi.14460
PMCID: PMC8363874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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