Article

DnaA modulates the gene expression and morphology of the Lyme disease spirochete

2024-06-08

Abstract excerpt

<h4>ABSTRACT</h4> All bacteria encode a multifunctional DNA-binding protein, DnaA, which initiates chromosomal replication. Despite having the most complex, segmented bacterial genome, little is known about Borrelia burgdorferi DnaA and its role in maintaining the spirochete’s physiology. In this work we utilized inducible CRISPR-interference and overexpression to modulate cellular levels of DnaA to better under...

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Literature Corpus work: 475cd1c5-bf66-537b-89f5-00e36c0de429
DOI: 10.1101/2024.06.08.598065

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