Article

Deubiquitinating enzyme USP44 suppresses hepatocellular carcinoma progression through inhibiting Hedgehog signaling and PDL1 expression

2023-08-25

Abstract excerpt

<title>Abstract</title> <p>Hepatocellular carcinoma (HCC) is one of the deadliest malignancies in the world. Research into the key genes that maintain the malignant behavior of cancer cells is crucial for the treatment of HCC. Here, we identify ubiquitin‐specific peptidase 44 (USP44), a member of deubiquitinase family, as a novel regulator of HCC progression. The tumor suppressive function of USP44 was evaluated...

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Literature Corpus work: 8a187987-4e98-5a0f-b7b5-aba07a9b4705
DOI: 10.21203/rs.3.rs-3209355/v1

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