Article

Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells

2022-09-04

Abstract excerpt

<h4>ABSTRACT</h4> The ADP-ribosyltransferase PARP7 modulates protein function by conjugating ADP-ribose to the side chains of acceptor amino acids. PARP7 has been shown to affect gene expression in prostate cancer cells and certain other cell types by mechanisms that include transcription factor ADP-ribosylation. Here, we use a recently developed catalytic inhibitor to PARP7, RBN2397, to study the effects of PARP...

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Literature Corpus work: 89f72ed6-a387-56ad-b8ac-d497eeb1f716
DOI: 10.1101/2022.09.02.506406

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