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Article

PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus.

The Biochemical journal - 13 Aug 2021

Kamata Teddy, Yang Chun-Song, Paschal Bryce M

Abstract excerpt

We recently described a signal transduction pathway that contributes to androgen receptor (AR) regulation based on site-specific ADP-ribosylation by PARP7, a mono-ADP-ribosyltransferase implicated in several human cancers. ADP-ribosylated AR is recognized by PARP9/DTX3L, a heterodimeric complex that contains an ADP-ribose reader (PARP9) and a ubiquitin E3 ligase (DTX3L). Here, we have characterized the cellular...

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Share to ADP Ribose Transferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34264286
DOI: 10.1042/BCJ20210378
PMCID: PMC9482820

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