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Article

Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer

20 Feb 2014

Abstract excerpt

Prostate cancer growth depends on androgen receptor signaling. Androgen ablation therapy induces expression of constitutively active androgen receptor splice variants that drive disease progression. Taxanes are a standard of care therapy in castration-resistant prostate cancer (CRPC); however, mechanisms underlying the clinical activity of taxanes are poorly understood. Recent work suggests that the microtubule...

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PMID: 24556717
DOI: 10.1158/0008-5472.can-13-2876

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