Back to search

Article

Unraveling the association between retinal thickness and Alzheimer's disease, and circulating total-tau levels: Insights from genetic evidence

2025-01-24

Abstract excerpt

<title>Abstract</title> <p>Background Observational studies have reported associations between retinal thickness and Alzheimer’s disease (AD); however, the causal relationship remains uncertain. Methods We investigated the potential causal relationship between retinal thickness and AD using Mendelian randomization (MR) and genetic colocalization analyses. Multiple genome-wide association studies (GWAS) of Europ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8973d0fd-f148-53f1-b223-af28b611363e
DOI
10.21203/rs.3.rs-5869988/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Unraveling the association between retinal thickness and Alzheimer's disease, and circulating total-tau levels: Insights from genetic evidenceDOI 10.21203/rs.3.rs-5869988/v1
Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypesSemantic proximity
Photoreceptor layer thinning is an early biomarker for age-related macular degeneration development: Epidemiological and genetic evidence from UK Biobank optical coherence tomography dataSemantic proximity
Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic healthSemantic proximity
Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohortSemantic proximity
Retinal Transcriptome-Wide Association Study Identifies Novel Alzheimer’s Disease Risk GenesSemantic proximity
Multi-omic spatial effects on high-resolution AI-derived retinal thicknessSemantic proximity
Genome-wide discovery reveals 30 loci for choroidal thickness and uncovers potential causal links with angle-closure glaucomaSemantic proximity
Relationship Between Retinal Layer Thickness and Genetic Susceptibility to Age-Related Macular Degeneration in Asian PopulationsSemantic proximity
Genome-wide association study of subfoveal choroidal thickness in a longitudinal cohort of older adultsSemantic proximity
Association between retinal nerve fiber layer thickness and psychiatric disorders: a Mendelian randomization studySemantic proximity
Genetic susceptibility to schizophrenia through neuroinflammatory pathways is associated with retinal thinning: Findings from the UK-BiobankSemantic proximity
Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.Semantic proximity
Select a neighboring publication to make it the new centre.