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Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health

24 Jan 2024

Abstract excerpt

The human retina is a multilayered tissue that offers a unique window into systemic health. Optical coherence tomography (OCT) is widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy in exquisite detail. We conducted genotypic and phenotypic analyses of retinal layer thicknesses using macular OCT images from 44,823 UK Biobank participants. We performed OCT layer cross-phenotype...

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PMID: 38266105
DOI: 10.1126/scitranslmed.adg4517

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