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Susceptibility to gingipains and transcriptomic response to <i>P. gingivalis</i> highlights the ribosome, hypothalamus, and cholinergic neurons

2020-08-10

Abstract excerpt

Porphyromonas gingivalis , a keystone species in the development of periodontal disease, is a suspected cause of Alzheimer’s disease. This bacterium is reliant on gingipain proteases, which cleave host proteins after arginine and lysine residues. To characterize gingipain susceptibility, we performed enrichment analyses of arginine and lysine proportion proteome-wide. Proteins in the SRP-dependent cotranslational...

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Identifiers and source

Literature Corpus work
8592de19-e99d-5ebd-93ed-0aa637640b5a
DOI
10.1101/2020.08.09.243402
Open publication

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Susceptibility to gingipains and transcriptomic response to <i>P. gingivalis</i> highlights the ribosome, hypothalamus, and cholinergic neuronsDOI 10.1101/2020.08.09.243402
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