Article

N6-methyladenosine regulation of mRNA translation is essential for early human erythropoiesis

2025-11-12

Abstract excerpt

N6-methyladenosine (m 6 A) is an abundant modification of mRNA with important regulatory roles in normal and malignant hematopoiesis. We previously reported that in human erythroid leukemia (HEL) cells, m 6 A mRNA marking selectively regulates translation of essential erythropoiesis genes required for in vitro differentiation and human erythroid colony formation. Here, we further investigated the timing and natu...

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Literature Corpus work: 89319a98-9f05-5259-80d0-0fc5f1988720
DOI: 10.1101/2025.11.10.687731

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