Tissue-specific genes as an underutilized resource in drug discovery

Abstract excerpt

<h4>ABSTRACT</h4> Tissue-specific genes are believed to be good drug targets due to improved safety. Here we show that this intuitive notion is not reflected in phase 1 and 2 clinical trials, despite the historic success of tissue-specific targets and their 2.3-fold overrepresentation among targets of marketed non-oncology drugs. We compare properties of tissue-specific genes and drug targets. We show that tissue...

Topics

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• Clinical Trials, Phase III as Topic
• Gene Expression Profiling
• Gene Regulatory Networks
• Genetic Predisposition to Disease
• Molecular Targeted Therapy
• Oligonucleotide Array Sequence Analysis
• Organ Specificity
• Proteomics

Identifiers and source

Literature Corpus work

88c939e4-c29a-55d6-8e58-f2dacea21fcf

DOI

10.1101/442780