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Article

Quantitative systems-level determinants of human genes targeted by successful drugs.

Genome research - 1 Feb 2008

Yao Lixia, Rzhetsky Andrey

Abstract excerpt

What makes a successful drug target? A target molecule with an appropriate (druggable) tertiary structure is a necessary but not the sufficient condition for success. Here we analyzed specific properties of human genes and proteins targeted by 919 FDA-approved drugs and identified several quantit...

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Identifiers

PMID: 18083776
DOI: 10.1101/gr.6888208
PMCID: PMC2203618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18083776-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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