Article
A dramatic impairment of the antitumor activity of human Vγ9Vδ2 T cells is induced by TGF-β through significant phenotype, transcriptomic and metabolic changes
2022-09-23
Abstract excerpt
Despite significant advances, the eradication of cancer remains a clinical challenge which justifies the urgent exploration of additional therapeutic strategies such as immunotherapies. Human peripheral Vγ9Vδ2 T cells represent an attractive candidate subset for designing safe, feasible and effective adoptive T cell transfer-based therapies. However, following their infiltration within tumors, γδ T cells are expos...
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Identifiers and source
- Literature Corpus work
- 88c41310-5d36-5775-b42a-c04a26c0dd26
- DOI
- 10.1101/2022.09.22.509026