Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The antitumor activity of human Vγ9Vδ2 T cells is impaired by TGF-β through significant phenotype, transcriptomic and metabolic changes.

Frontiers in immunology - 1 Jan 2022

Rafia Chirine, Loizeau Clément, Renoult Ophélie, Harly Christelle, Pecqueur Claire, Joalland Noémie, Scotet Emmanuel

Abstract excerpt

Despite significant advances, the eradication of cancer remains a clinical challenge which justifies the urgent exploration of additional therapeutic strategies such as immunotherapies. Human peripheral Vγ9Vδ2 T cells represent an attractive candidate subset for designing safe, feasible and effective adoptive T cell transfer-based therapies. However, following their infiltration within tumors, γδ T cells are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Receptors, Antigen, T-Cell, gamma-delta

Share to T-Lymphocytes

Share to Transcriptome

Share to Transforming Growth Factor beta

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 36741364
DOI: 10.3389/fimmu.2022.1066336
PMCID: PMC9893774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The antitumor activity of human Vγ9Vδ2 T cells is impaired by TGF-β through significant phenotype, transcriptomic and metabolic changes.PMID 36741364Read ↗

A dramatic impairment of the antitumor activity of human Vγ9Vδ2 T cells is induced by TGF-β through significant phenotype, transcriptomic and metabolic changesSemantic proximity Read ↗

Emerging Challenges of Preclinical Models of Anti-tumor Immunotherapeutic Strategies Utilizing Vγ9Vδ2 T Cells.Semantic proximity Read ↗

Cancer Immunotherapy Using γδT Cells: Dealing with DiversitySemantic proximity Read ↗

Transforming Growth Factor-β: A Multifunctional Regulator of Cancer ImmunitySemantic proximity Read ↗

Optimized Multiple Amplification Protocol for the Production of Allogeneic Human Vγ9Vδ2 T Lymphocytes for Adoptive Cell Transfer ImmunotherapySemantic proximity Read ↗

Human γδ T cells in the tumor microenvironment: Key insights for advancing cancer immunotherapySemantic proximity Read ↗

Role of γδ T Cells in Cancer Progression and Therapy.Semantic proximity Read ↗

The Love-Hate Relationship Between TGF-β Signaling and the Immune System During Development and TumorigenesisSemantic proximity Read ↗

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillanceSemantic proximity Read ↗

TGF-Beta: a Master Switch in Tumor ImmunitySemantic proximity Read ↗

CD29 marks superior cytotoxic human T cellsSemantic proximity Read ↗

TGF-beta: a master immune regulatorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.