Article

Impact of the Temperature on the Interactions Between Common Variants of the SARS-CoV-2 Receptor Binding Domain and the Human ACE2

2022-05-11

Abstract excerpt

Several key mutations in the Spike protein receptor binding domain (RBD) have been identified to influence its affinity for the human Angiotensin-Converting Enzyme 2 (ACE2). Here, we perform a comparative study of the ACE2 binding to the wild type (Wuhan) RBD and some of its variants: Alpha B.1.1.7, Beta B.1.351, Delta B.1.617.2, Kappa B.1.617.1, B.1.1.7+L452R and Omicron B.1.1.529. Using a coiled-coil mediated te...

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Identifiers and source

Literature Corpus work: 88853284-75b1-562c-b0e5-a76f2ac5e949
DOI: 10.21203/rs.3.rs-1585804/v1

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