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Article

Untangling the roles of RNA helicases in antiviral innate immunity

9 Dec 2021

Abstract excerpt

One of the first layers of protection that metazoans put in place to defend themselves against viruses rely on the use of proteins containing DExD/H-box helicase domains. These members of the duplex RNA-activated ATPase (DRA) family act as sensors of double-stranded RNA (dsRNA) molecules, a universal marker of viral infections. DRAs can be classified into 2 subgroups based on their mode of action: They can either...

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PMID: 34882751
DOI: 10.1371/journal.ppat.1010072

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