Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circulating IL-17 a as a downstream inflammatory indicator of depression: Insights from mendelian randomization and animal experiments.

Cytokine - 1 Aug 2026

Lu Zhenchen, Yang Qiaoyu, Hu Shansong, Wu Han, Lu Liuliu, Shao Yiwei, Ye Bingqing, Li Li, Li Zeng, Li Rong, Liu Zhicheng

Abstract excerpt

BACKGROUND: Previous studies have established a strong link between central nervous system inflammation and depression development. However, the role and function of circulating cytokines in depression remain a topic of debate. METHODS: Bidirectional MR analyses used GWAS data from the GWAS Catalog, UK Biobank, and IEU database, including two depression cohorts and 41 circulating cytokines. Animal experiments...

Topics

Join the communities discussing this publication.

Depression
Genome-Wide Association Study
Inflammation
Interleukin-17
Interleukin-1beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 42250465
DOI: 10.1016/j.cyto.2026.157175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circulating IL-17 a as a downstream inflammatory indicator of depression: Insights from mendelian randomization and animal experiments.PMID 42250465Read ↗

Genetic association and drug target exploration of inflammation-related proteins with risk of major depressive disorder.Semantic proximity Read ↗

Genetic Contributions of Inflammation to DepressionSemantic proximity Read ↗

Inflammation and depression.Semantic proximity Read ↗

Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK BiobankSemantic proximity Read ↗

Cross-species evidence for the role of interleukin-33 in depression risk.Semantic proximity Read ↗

Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP studySemantic proximity Read ↗

Assessing the causal relationship between immune cell traits and depression by Mendelian randomization analysis.Semantic proximity Read ↗

The role of pro-inflammatory cytokine gene polymorphisms in major depressive disorder: a systematic review.Semantic proximity Read ↗

The inflammatory cytokines: molecular biomarkers for major depressive disorder?Semantic proximity Read ↗

The role of inflammatory biomarkers in the association between rheumatoid arthritis and depression: a Mendelian randomization study.Semantic proximity Read ↗

T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviorsSemantic proximity Read ↗

A chicken and egg scenario in psychoneuroimmunology: Bidirectional mechanisms linking cytokines and depressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.