Article

Behavioral and Pharmacological Validation of the Differential Reinforcement of Low-Rate Behavior Paradigm in Non-Human Primates

2025-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Depression remains a leading cause of disability worldwide, yet the predictive validity of many preclinical behavioral assays for antidepressant efficacy remains limited. The Differential Reinforcement of Low-Rate Behavior (DRL) task has classically been used in rodents to identify antidepressant-like effects, but its utility in non-human primates (NHPs) has not been established. Here, we adapte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 87ea3ea5-5f93-5c4d-a8b3-8ff64640cbc8
DOI: 10.1101/2025.06.02.657510

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Behavioral and Pharmacological Validation of the Differential Reinforcement of Low-Rate Behavior Paradigm in Non-Human PrimatesDOI 10.1101/2025.06.02.657510Read

Ketamine improves anhedonic phenotypes across species: Translational evidence from the Probabilistic Reward TaskSemantic proximity Read

Phenotypes of reinforcement sensitivity as predictors of the response to acute antidepressant treatment in rats.Semantic proximity Read

Conditioned versus innate effort-based tasks reveal divergence in antidepressant effect on motivational state in male miceSemantic proximity Read

Editing of serotonin 2C receptor mRNA in the prefrontal cortex characterizes high-novelty locomotor response behavioral trait.Semantic proximity Read

Macaques exhibit a naturally-occurring depression similar to humans.Semantic proximity Read

Depression-like behavioral phenotypes by social and social plus visual isolation in the adult female Macaca fascicularis.Semantic proximity Read

Animal models in psychedelic research – Tripping over translationSemantic proximity Read

Toward an objective characterization of an anhedonic phenotype: a signal-detection approach.Semantic proximity Read

The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trialSemantic proximity Read

Differences in trait impulsivity do not bias the response to pharmacological drug challenge in the rat five-choice serial reaction time task.Semantic proximity Read

Cross-species modeling and enhancement of cognitive control with striatal brain stimulationSemantic proximity Read

A Methodological Checklist for fMRI Drug Cue Reactivity Studies: Development and Expert ConsensusSemantic proximity Read