Article

Single‐cell and spatial transcriptomics reveal ACKR1+ endothelial cells associated with transcytosis in Leprosy

2024-01-04

Abstract excerpt

<h4>Background: </h4> Leprosy exhibits a dysregulated immune response, leading to excessive and inefficient inflammatory action. This can result in nerve damage, granuloma formation, and other clinical manifestations. Methods Single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomic analyses were applied to explore the intricate cellular landscape of leprosy, focusing on endothelial cells. The study encom...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 87c7c6e5-5c61-53ee-9c4d-d1feb9d3a378
DOI: 10.21203/rs.3.rs-3829511/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single‐cell and spatial transcriptomics reveal ACKR1+ endothelial cells associated with transcytosis in LeprosyDOI 10.21203/rs.3.rs-3829511/v1Read

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy GranulomasSemantic proximity Read

Type 1 reaction leprosy patients display distinct immune-regulatory capacity before onset of symptomsSemantic proximity Read

Single-cell RNA sequencing reveals distinct immunology profiles in human keloidSemantic proximity Read

A new paradigm for leprosy diagnosis based on host gene expression Insights from leprosy lesions transcriptomicsSemantic proximity Read

<i>Mycobacterium leprae</i> and host immune transcriptomic signatures for reactional states in leprosySemantic proximity Read

The Use of Single-Cell RNA-Sequencing and Spatial Transcriptomics in Understanding the Pathogenesis and Treatment of Skin DiseasesSemantic proximity Read

Immune disease dialogue of chemokine-based cell communications as revealed by single-cell RNA sequencing meta-analysisSemantic proximity Read

Single-cell transcriptomics in dermatologySemantic proximity Read

Single-Cell and Spatial Transcriptomic Analysis of Human Skin Delineates Intercellular Communication and Pathogenic CellsSemantic proximity Read

Single cell transcriptome profiling reveals pathogenesis of bullous pemphigoidSemantic proximity Read

Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin PathologySemantic proximity Read

Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseasesSemantic proximity Read