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Confirmatory evidence that miR-15a and miR-16 regulate BCL2 at the post-transcriptional level

2026-03-04

Abstract excerpt

The microRNAs miR-15a and miR-16 are key regulators of the anti-apoptotic oncogene BCL2, playing a significant role in tumorigenesis. These miRNAs function as tumor suppressors by directly targeting BCL2, whose overexpression contributes to cell survival and resistance to therapy in multiple malignancies, including chronic lymphocytic leukemia (CLL). The downregulation or deletion miR-15a/miR-16-1 cluster located...

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Literature Corpus work
87abea80-f017-540c-ae50-1867436a7998
DOI
10.64898/2026.03.02.708996
Open publication

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Confirmatory evidence that miR-15a and miR-16 regulate BCL2 at the post-transcriptional levelDOI 10.64898/2026.03.02.708996
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